Oppenheim was born in 1975 in New York City, where she currently lives and works. She received her BA from Brown University in 1998, and later an MFA from the Milton Avery Graduate School for the Arts at Bard College in 2001. She also attended the Whitney Independent Study Program and the Rijksakademie van beeldedne kunsten in Amsterdam.
Oppenheim has been the subject of solo exhibitions at MOCA Cleveland (2017), the FRAC Champagne-Ardenne (2015), Kunstverein in Hamburg (2014), Grazer Kunstverein (2014) and notable group exhibitions including the forthcoming Braided Histories: Modernist Abstraction and Woven Forms (working title), National Gallery of Art, Washington, D.C. (will travel to Los Angeles County Museum of Art and National Gallery of Canada, Ottawa), Afterlives, The Jewish Museum, New York (2021), Off the Record, Guggenheim Museum, New York (2021), Light, Paper, Process: Reinventing Photography, The Getty Center, Los Angeles (2015), Photo-Poetics, Deutsche Bank Kunsthalle, Berlin and Guggenheim Museum, New York (2015), and New Photography at The Museum of Modern Art (2013).
Her work is held in the permanent collections of the Museum of Modern Art, New York, The Solomon R. Guggenheim Museum, New York, The J. Paul Getty Museum, Los Angeles, Israel Museum, Jerusalem, Stedelijk Museum Amsterdam, Victoria & Albert Museum, London, MIT List Visual Arts Center, Cambridge, and Milwaukee Art Museum, among others.